André Laurent O'Neil engages in many diverse musical projects, ranging from performing on period instruments (including the viola da gamba and fortepiano), to teaching modern cello, playing chamber music, and composing. He is Principal Cellist of the Schenectady Symphony Orchestra, Affiliate Artist at Union College, teaches at Schenectady County Community College School of Music, and plays with Musicians of Ma'alwyck. In the early music field he is principal continuo baroque cellist and gamba player for New Trinity Baroque, with whom he performs in Atlanta (US), Belgrade (Serbia), and London (UK).

During the pandemic André released a CD recording of all six of Johann Sebastian Bach's Solo Cello Suites, about which Atlanta's EarRelevant mused: "What shines through these unhurried and ruminative performances of the Suites is O'Neil's obvious love and deep understanding of these iconic works."

André loves gardening, hiking, cross-country skiing, and creative writing.